Version 5.4
Homo sapiens Gene: KLHL13
Summary
InnateDB Gene IDBG-83132.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL13
Gene Name kelch-like 13 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000003096
Encoded Proteins
IDBP-83134
kelch-like 13 (Drosophila)
IDBP-83136
kelch-like 13 (Drosophila)
IDBP-83138
kelch-like 13 (Drosophila)
IDBP-83140
kelch-like 13 (Drosophila)
IDBP-379539
kelch-like 13 (Drosophila)
IDBP-379542
kelch-like 13 (Drosophila)
IDBP-474096
kelch-like 13 (Drosophila)
IDBP-592603
kelch-like 13 (Drosophila)
IDBP-589321
kelch-like 13 (Drosophila)
IDBP-600155
kelch-like 13 (Drosophila)
IDBP-589946
kelch-like 13 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:117897813-118117340
Strand Reverse strand
Band q24
Transcripts
ENST00000371882 ENSP00000360949
ENST00000262820 ENSP00000262820
ENST00000371878 ENSP00000360945
ENST00000371876 ENSP00000360943
ENST00000447671 ENSP00000412640
ENST00000453826 ENSP00000393807
ENST00000469946 ENSP00000419803
ENST00000541812 ENSP00000444450
ENST00000540167 ENSP00000441029
ENST00000539496 ENSP00000443191
ENST00000545703 ENSP00000440707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0007067 mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036782
View Gene Order
ENSBTAG00000000501
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.348262
RefSeq NM_001168299 NM_001168300 NM_001168301 NM_001168302 NM_001168303 NM_033495
HUGO
OMIM
CCDS CCDS14571 CCDS55479 CCDS55480 CCDS55481
HPRD 06461
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca