Version 5.4
Bos taurus Gene: KLHL13
Summary
InnateDB Gene IDBG-629488.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL13
Gene Name Kelch-like protein 13
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000501
Encoded Proteins
IDBP-680890
Kelch-like protein 13
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003096:
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:1975398-2038024
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000639 ENSBTAP00000000639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0016567 protein ubiquitination
GO:0051301 cell division
Cellular Component
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000003096
View Gene Order
ENSMUSG00000036782
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_230745
Immune System pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_229531
Adaptive Immune System pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt A6QQY2
TrEMBL
UniProt Splice Variant
Entrez Gene 528138
UniGene Bt.16194
RefSeq NM_001102511 XM_005227423 XM_005227424 XM_005227425
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC150039
GenPept AAI50040
RNA Seq Atlas 528138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca