Version 5.4
Homo sapiens Gene: SLIT1
Summary
InnateDB Gene IDBG-84201.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLIT1
Gene Name slit homolog 1 (Drosophila)
Synonyms MEGF4; SLIL1; SLIT-1; SLIT3
Species Homo sapiens
Ensembl Gene ENSG00000187122
Encoded Proteins
IDBP-84203
slit homolog 1 (Drosophila)
IDBP-84205
slit homolog 1 (Drosophila)
IDBP-84211
slit homolog 1 (Drosophila)
IDBP-84213
slit homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 10:96998038-97185920
Strand Reverse strand
Band q24.1
Transcripts
ENST00000266058 ENSP00000266058
ENST00000371070 ENSP00000360109
ENST00000314867 ENSP00000315005
ENST00000371041 ENSP00000360080
ENST00000456008
ENST00000494968
ENST00000497714
ENST00000475285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0048495 Roundabout binding
Biological Process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008045 motor neuron axon guidance
GO:0021510 spinal cord development
GO:0021772 olfactory bulb development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0022029 telencephalon cell migration
GO:0031290 retinal ganglion cell axon guidance
GO:0033563 dorsal/ventral axon guidance
GO:0040023 establishment of nucleus localization
GO:0048812 neuron projection morphogenesis
GO:0048843 negative regulation of axon extension involved in axon guidance
GO:0048846 axon extension involved in axon guidance
GO:0048853 forebrain morphogenesis
GO:0050919 negative chemotaxis
GO:0051964 negative regulation of synapse assembly
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025020
View Gene Order
ENSBTAG00000043991
Not yet available
Pathways
NETPATH
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632082 Hs.721483
RefSeq NM_003061
HUGO
OMIM
CCDS CCDS7453
HPRD 04773
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca