Version 5.4
Homo sapiens Gene: TNFRSF18
Summary
InnateDB Gene IDBG-84584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF18
Gene Name tumor necrosis factor receptor superfamily, member 18
Synonyms AITR; CD357; GITR; GITR-D
Species Homo sapiens
Ensembl Gene ENSG00000186891
Encoded Proteins
IDBP-84586
tumor necrosis factor receptor superfamily, member 18
IDBP-84588
tumor necrosis factor receptor superfamily, member 18
IDBP-84590
tumor necrosis factor receptor superfamily, member 18
IDBP-722082
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19760073
TNFRSF18 is expressed in several cells and tissues, including T and Natural Killer (NK) cells and is activated by its ligand, GITRL, mainly expressed on Antigen Presenting Cells (APCs) and endothelial cells and is a modulator of immune response and inflammation.
Entrez Gene
Summary This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:1203508-1206691
Strand Reverse strand
Band p36.33
Transcripts
ENST00000379268 ENSP00000368570
ENST00000328596 ENSP00000328207
ENST00000379265 ENSP00000368567
ENST00000486728 ENSP00000462735
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.212680
RefSeq NM_004195 NM_148901 NM_148902
HUGO
OMIM
CCDS CCDS10 CCDS30552 CCDS9
HPRD 04879
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca