Homo sapiens Gene: TNFRSF18 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-84584.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TNFRSF18 | ||||||||||||||||||
Gene Name | tumor necrosis factor receptor superfamily, member 18 | ||||||||||||||||||
Synonyms | AITR; CD357; GITR; GITR-D | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000186891 | ||||||||||||||||||
Encoded Proteins |
tumor necrosis factor receptor superfamily, member 18
tumor necrosis factor receptor superfamily, member 18
tumor necrosis factor receptor superfamily, member 18
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||
Summary |
TNFRSF18 is expressed in several cells and tissues, including T and Natural Killer (NK) cells and is activated by its ligand, GITRL, mainly expressed on Antigen Presenting Cells (APCs) and endothelial cells and is a modulator of immune response and inflammation.
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Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 1:1203508-1206691 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p36.33 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Cytokine-cytokine receptor interaction pathway
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INOH | |||||||||||||||||||
PID NCI |
Downstream signaling in naïve CD8+ T cells
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.212680 | ||||||||||||||||||
RefSeq | NM_004195 NM_148901 NM_148902 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS10 CCDS30552 CCDS9 | ||||||||||||||||||
HPRD | 04879 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||