Homo sapiens Gene: CPN1
Summary
InnateDB Gene IDBG-86249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPN1
Gene Name carboxypeptidase N, polypeptide 1
Synonyms CPN; SCPN;
Species Homo sapiens
Ensembl Gene ENSG00000120054
Encoded Proteins
carboxypeptidase N, polypeptide 1
carboxypeptidase N, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100042193-100081877
Strand Reverse strand
Band q24.2
Transcripts
ENST00000370418 ENSP00000359446
ENST00000441382 ENSP00000410895
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0010815 bradykinin catabolic process
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Insulin processing pathway
Peptide hormone metabolism pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P15169
TrEMBL B1AP58
UniProt Splice Variant
Entrez Gene 1369
UniGene Hs.2246
RefSeq NM_001308
HUGO HGNC:2312
OMIM 603103
CCDS CCDS7486
HPRD 09120
IMGT
EMBL AK313972 AL441886 BC027897 CH471066 X14329
GenPept AAH27897 BAG36687 CAA32507 EAW49848
RNA Seq Atlas 1369