Version 5.4
Homo sapiens Gene: CPN1
Summary
InnateDB Gene IDBG-86249.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPN1
Gene Name carboxypeptidase N, polypeptide 1
Synonyms CPN; SCPN
Species Homo sapiens
Ensembl Gene ENSG00000120054
Encoded Proteins
IDBP-86251
carboxypeptidase N, polypeptide 1
IDBP-384324
carboxypeptidase N, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100042193-100081877
Strand Reverse strand
Band q24.2
Transcripts
ENST00000370418 ENSP00000359446
ENST00000441382 ENSP00000410895
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0010815 bradykinin catabolic process
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025196
View Gene Order
ENSBTAG00000023941
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.2246
RefSeq NM_001308
HUGO
OMIM
CCDS CCDS7486
HPRD 09120
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca