Homo sapiens Gene: WNT8B
Summary
InnateDB Gene IDBG-86499.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT8B
Gene Name wingless-type MMTV integration site family, member 8B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000075290
Encoded Proteins
wingless-type MMTV integration site family, member 8B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%%, 86%% and 71%% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:100463041-100483744
Strand Forward strand
Band q24.31
Transcripts
ENST00000343737 ENSP00000340677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
Biological Process
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007369 gastrulation
GO:0007399 nervous system development
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0045165 cell fate commitment
GO:0048263 determination of dorsal identity
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
GPCR ligand binding pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
Wnt lrp6 signalling [Biocarta view]
PID NCI
Cross-References
SwissProt Q93098
TrEMBL
UniProt Splice Variant
Entrez Gene 7479
UniGene Hs.421281
RefSeq NM_003393
HUGO HGNC:12789
OMIM 601396
CCDS CCDS7494
HPRD
IMGT
EMBL AB073637 AL133352 AL359759 X91940 Y11094 Y11108
GenPept BAB83924 CAA63017 CAA71968 CAA71994 CAH71991 CAH73565
RNA Seq Atlas 7479