InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT8B

Summary

InnateDB Gene

IDBG-86499.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT8B

Gene Name

wingless-type MMTV integration site family, member 8B

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000075290

Encoded Proteins

IDBP-86501

wingless-type MMTV integration site family, member 8B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%%, 86%% and 71%% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:100463041-100483744

Strand

Forward strand

Band

q24.31

Transcripts

ENST00000343737

ENSP00000340677

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007369	gastrulation
GO:0007399	nervous system development
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0045165	cell fate commitment
GO:0048263	determination of dorsal identity
GO:0071300	cellular response to retinoic acid