Version 5.4
Homo sapiens Gene: UBR2
Summary
InnateDB Gene IDBG-87239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBR2
Gene Name ubiquitin protein ligase E3 component n-recognin 2
Synonyms bA49A4.1; C6orf133; dJ242G1.1; dJ392M17.3
Species Homo sapiens
Ensembl Gene ENSG00000024048
Encoded Proteins
IDBP-87241
ubiquitin protein ligase E3 component n-recognin 2
IDBP-87243
ubiquitin protein ligase E3 component n-recognin 2
IDBP-87245
ubiquitin protein ligase E3 component n-recognin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:42564062-42693504
Strand Forward strand
Band p21.1
Transcripts
ENST00000372903 ENSP00000361994
ENST00000372901 ENSP00000361992
ENST00000372899 ENSP00000361990
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0070728 leucine binding
Biological Process
GO:0006342 chromatin silencing
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0030163 protein catabolic process
GO:0032007 negative regulation of TOR signaling
GO:0033522 histone H2A ubiquitination
GO:0071233 cellular response to leucine
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023977
View Gene Order
ENSBTAG00000005967
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8IWV8
TrEMBL B3KXG6
UniProt Splice Variant
Entrez Gene 23304
UniGene Hs.529925 Hs.595020
RefSeq NM_001184801 NM_015255 XM_005248965 XM_005248966
HUGO HGNC:21289
OMIM 609134
CCDS CCDS4870 CCDS55001
HPRD
IMGT
EMBL AB002347 AK125795 AK127310 AL049843 AL136223 AL391814 AY061884 BC024217 BC064512
GenPept AAH24217 AAH64512 AAL32101 BAA20806 BAC86295 BAG54478 CAI14737 CAI14738 CAI19919 CAI19920 CAI20399 CAI95298 CAI95666 CAI95685
RNA Seq Atlas 23304

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca