InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFRSF1B

Summary

InnateDB Gene

IDBG-90091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF1B

Gene Name

tumor necrosis factor receptor superfamily, member 1B

Synonyms

CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80

Species

Homo sapiens

Ensembl Gene

ENSG00000028137

Encoded Proteins

IDBP-90093

tumor necrosis factor receptor superfamily, member 1B

IDBP-584644

tumor necrosis factor receptor superfamily, member 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17220297

TNFRSF1B signalling induces selective BIRC2-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signalling.

Entrez Gene

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:12167003-12209228

Strand

Forward strand

Band

p36.22

Transcripts

ENST00000376259	ENSP00000365435
ENST00000492361
ENST00000489921
ENST00000536782	ENSP00000440425

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	45 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007568	aging
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032496	response to lipopolysaccharide
GO:0045087	innate immune response (InnateDB)
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0071222	cellular response to lipopolysaccharide
GO:0071363	cellular response to growth factor stimulus
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043196	varicosity
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028599

View Gene Order

ENSBTAG00000024928

Not yet available

Pathways

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04920

Adipocytokine signaling pathway pathway

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

INOH

PID NCI

tnfpathway

TNF receptor signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.256278 Hs.604011 Hs.619763

RefSeq

NM_001066

HUGO

OMIM

CCDS

CCDS145

HPRD

01862

IMGT

EMBL

GenPept

RNA Seq Atlas