Homo sapiens Gene: TNFRSF1B
Summary
InnateDB Gene IDBG-90091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFRSF1B
Gene Name tumor necrosis factor receptor superfamily, member 1B
Synonyms CD120b; p75; p75TNFR; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80;
Species Homo sapiens
Ensembl Gene ENSG00000028137
Encoded Proteins
tumor necrosis factor receptor superfamily, member 1B
tumor necrosis factor receptor superfamily, member 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TNFRSF1B signalling induces selective BIRC2-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signalling.
Entrez Gene
Summary The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:12167003-12209228
Strand Forward strand
Band p36.22
Transcripts
ENST00000376259 ENSP00000365435
ENST00000492361
ENST00000489921
ENST00000536782 ENSP00000440425
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 48 [view]
Protein-Protein 45 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007568 aging
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032496 response to lipopolysaccharide
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0050779 RNA destabilization
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0071222 cellular response to lipopolysaccharide
GO:0071363 cellular response to growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0043196 varicosity
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Adipocytokine signaling pathway pathway
Amyotrophic lateral sclerosis (ALS) pathway
INOH
PID BIOCARTA
Tnfr2 signaling pathway [Biocarta view]
PID NCI
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.256278 Hs.604011 Hs.619763
RefSeq NM_001066
HUGO
OMIM
CCDS CCDS145
HPRD 01862
IMGT
EMBL
GenPept
RNA Seq Atlas