Version 5.4
Homo sapiens Gene: PDPN
Summary
InnateDB Gene IDBG-90582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDPN
Gene Name podoplanin
Synonyms AGGRUS; GP36; Gp38; GP40; HT1A-1; OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A
Species Homo sapiens
Ensembl Gene ENSG00000162493
Encoded Proteins
IDBP-90584
podoplanin
IDBP-90586
podoplanin
IDBP-90588
podoplanin
IDBP-481288
podoplanin
IDBP-475878
podoplanin
IDBP-477921
podoplanin
IDBP-484192
podoplanin
IDBP-483956
podoplanin
IDBP-475028
podoplanin
IDBP-474718
podoplanin
IDBP-811504
podoplanin
IDBP-811510
podoplanin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:13583465-13617957
Strand Forward strand
Band p36.21
Transcripts
ENST00000376061 ENSP00000365229
ENST00000376057 ENSP00000365225
ENST00000294489 ENSP00000294489
ENST00000506205 ENSP00000421742
ENST00000510906 ENSP00000426302
ENST00000509009 ENSP00000422977
ENST00000513143 ENSP00000425304
ENST00000487038 ENSP00000427537
ENST00000475043 ENSP00000426063
ENST00000488631 ENSP00000426210
ENST00000621990 ENSP00000478125
ENST00000617617 ENSP00000479591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000902 cell morphogenesis
GO:0001946 lymphangiogenesis
GO:0006693 prostaglandin metabolic process
GO:0006928 cellular component movement
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0008360 regulation of cell shape
GO:0010572 positive regulation of platelet activation
GO:0016337 single organismal cell-cell adhesion
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0035239 tube morphogenesis
GO:0048286 lung alveolus development
GO:0051272 positive regulation of cellular component movement
GO:0055093 response to hyperoxia
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031528 microvillus membrane
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028583
View Gene Order
ENSBTAG00000001788
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10630
UniGene Hs.468675
RefSeq NM_001006624 NM_001006625 NM_006474 NM_198389 XM_006710295
HUGO HGNC:29602
OMIM 608863
CCDS CCDS30602 CCDS41266 CCDS44060 CCDS53270
HPRD 16398
IMGT
EMBL
GenPept
RNA Seq Atlas 10630

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca