Homo sapiens Gene: RGS10
Summary
InnateDB Gene IDBG-91166.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS10
Gene Name regulator of G-protein signaling 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000148908
Encoded Proteins
regulator of G-protein signaling 10
regulator of G-protein signaling 10
regulator of G-protein signaling 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:119499828-119542708
Strand Reverse strand
Band q26.11
Transcripts
ENST00000369103 ENSP00000358099
ENST00000369101 ENSP00000358097
ENST00000392865 ENSP00000376605
ENST00000469575
ENST00000473563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043679 axon terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
KEGG
INOH
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt O43665
TrEMBL
UniProt Splice Variant
Entrez Gene 6001
UniGene
RefSeq NM_001005339 NM_002925
HUGO HGNC:9992
OMIM 602856
CCDS CCDS31294 CCDS41572
HPRD
IMGT
EMBL AC012468 AF045229 AF368902 AF493934 AK290773 AL355273 BC009361 CH471066 CR457008
GenPept AAC03783 AAH09361 AAK52979 AAM12648 BAF83462 CAG33289 CAI16486 CAI16488 EAW49389 EAW49390
RNA Seq Atlas 6001