Homo sapiens Gene: MPP1
Summary
InnateDB Gene IDBG-92097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPP1
Gene Name membrane protein, palmitoylated 1, 55kDa
Synonyms AAG12; DXS552E; EMP55; MRG1; PEMP;
Species Homo sapiens
Ensembl Gene ENSG00000130830
Encoded Proteins
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
membrane protein, palmitoylated 1, 55kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154778684-154821007
Strand Reverse strand
Band q28
Transcripts
ENST00000369534 ENSP00000358547
ENST00000369531 ENSP00000358544
ENST00000393531 ENSP00000377165
ENST00000393529 ENSP00000377163
ENST00000413259 ENSP00000400155
ENST00000439370 ENSP00000400700
ENST00000453245 ENSP00000410888
ENST00000428488 ENSP00000391701
ENST00000417435 ENSP00000389321
ENST00000491955
ENST00000482757
ENST00000494170
ENST00000462825
ENST00000493871
ENST00000475943
ENST00000488754
ENST00000488694
ENST00000471821
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004385 guanylate kinase activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0046939 nucleotide phosphorylation
GO:0090022 regulation of neutrophil chemotaxis
Cellular Component
GO:0005622 intracellular
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0032420 stereocilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.496984
RefSeq NM_001166460 NM_001166461 NM_001166462 NM_002436
HUGO
OMIM
CCDS CCDS14762 CCDS55544 CCDS55545
HPRD 02370
IMGT
EMBL
GenPept
RNA Seq Atlas