Homo sapiens Gene: TBX18
Summary
InnateDB Gene IDBG-93971.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBX18
Gene Name T-box 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000112837
Encoded Proteins
T-box 18
T-box 18
T-box 18
T-box 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:84687351-84764519
Strand Reverse strand
Band q14.3
Transcripts
ENST00000369663 ENSP00000358677
ENST00000606784 ENSP00000475873
ENST00000607343
ENST00000606521
ENST00000606325 ENSP00000475498
ENST00000606621 ENSP00000476137
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001756 somitogenesis
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0003163 sinoatrial node development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007605 sensory perception of sound
GO:0009948 anterior/posterior axis specification
GO:0016331 morphogenesis of embryonic epithelium
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051145 smooth muscle cell differentiation
GO:0060829 negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0072189 ureter development
GO:0090103 cochlea morphogenesis
GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL U3KQ31 U3KQH2 U3KQQ9
UniProt Splice Variant
Entrez Gene 9096
UniGene
RefSeq NM_001080508
HUGO HGNC:11595
OMIM 604613
CCDS CCDS34495
HPRD
IMGT
EMBL AL035694 AL590143
GenPept
RNA Seq Atlas 9096