InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TBX18

Summary

InnateDB Gene

IDBG-93971.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBX18

Gene Name

T-box 18

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112837

Encoded Proteins

IDBP-93975

T-box 18

IDBP-809546

T-box 18

IDBP-809565

T-box 18

IDBP-809566

T-box 18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:84687351-84764519

Strand

Reverse strand

Band

q14.3

Transcripts

ENST00000369663	ENSP00000358677
ENST00000606784	ENSP00000475873
ENST00000607343
ENST00000606521
ENST00000606325	ENSP00000475498
ENST00000606621	ENSP00000476137

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001756	somitogenesis
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003163	sinoatrial node development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007605	sensory perception of sound
GO:0009948	anterior/posterior axis specification
GO:0016331	morphogenesis of embryonic epithelium
GO:0022409	positive regulation of cell-cell adhesion
GO:0030154	cell differentiation
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051145	smooth muscle cell differentiation
GO:0060829	negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0072189	ureter development
GO:0090103	cochlea morphogenesis
GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032419

View Gene Order

ENSBTAG00000018161

Not yet available

Cross-References

SwissProt

TrEMBL

U3KQ31 U3KQQ9

UniProt Splice Variant

Entrez Gene

9096

UniGene

RefSeq

NM_001080508

HUGO

HGNC:11595

OMIM

604613

CCDS

CCDS34495

HPRD

IMGT

EMBL

AL035694 AL590143

GenPept

RNA Seq Atlas

9096