Homo sapiens Gene: ORC3
Summary
InnateDB Gene IDBG-94195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC3
Gene Name origin recognition complex, subunit 3
Synonyms LAT; LATHEO; ORC3L;
Species Homo sapiens
Ensembl Gene ENSG00000135336
Encoded Proteins
origin recognition complex, subunit 3
origin recognition complex, subunit 3
origin recognition complex, subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:87590067-87667453
Strand Forward strand
Band q15
Transcripts
ENST00000257789 ENSP00000257789
ENST00000392844 ENSP00000376586
ENST00000468486
ENST00000478028
ENST00000546266 ENSP00000444695
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 44 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0061351 neural precursor cell proliferation
Cellular Component
GO:0000808 origin recognition complex
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Cell Cycle pathway
Association of licensing factors with the pre-replicative complex pathway
Removal of licensing factors from origins pathway
E2F mediated regulation of DNA replication pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the ORC complex at the origin of replication pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
Cross-References
SwissProt Q9UBD5
TrEMBL U3KQL3
UniProt Splice Variant
Entrez Gene 23595
UniGene Hs.410228 Hs.603122 Hs.735758
RefSeq NM_181837 XM_005248705 XM_005248706 NM_012381 NM_001197259 XM_005248704
HUGO HGNC:8489
OMIM 604972
CCDS CCDS5012 CCDS43486 CCDS56440
HPRD 05398
IMGT
EMBL AF093535 AF125507 AF135044 AK222795 AK303195 AK315911 AL080116 AL133211 AL451126 AY623113 BC035494 BC047689 U50950
GenPept AAA96313 AAD18057 AAD30282 AAD40220 AAH35494 AAH47689 AAT38109 BAD96515 BAG64287 BAH14282 CAB45715 CAI10900 CAI21539 CAM13063 CAM28255
RNA Seq Atlas 23595