Homo sapiens Gene: GRIK2
Summary
InnateDB Gene IDBG-94705.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRIK2
Gene Name glutamate receptor, ionotropic, kainate 2
Synonyms EAA4; GLR6; GluK2; GLUK6; GLUR6; MRT6;
Species Homo sapiens
Ensembl Gene ENSG00000164418
Encoded Proteins
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
glutamate receptor, ionotropic, kainate 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:101398788-102070083
Strand Forward strand
Band q16.3
Transcripts
ENST00000369138 ENSP00000358134
ENST00000369137 ENSP00000358133
ENST00000318991 ENSP00000313276
ENST00000358361 ENSP00000351128
ENST00000369134 ENSP00000358130
ENST00000413795 ENSP00000405596
ENST00000421544 ENSP00000397026
ENST00000455610 ENSP00000391988
ENST00000436862 ENSP00000407140
ENST00000487395
ENST00000487161
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004970 ionotropic glutamate receptor activity
GO:0005215 transporter activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005515 protein binding
GO:0008066 glutamate receptor activity
GO:0015277 kainate selective glutamate receptor activity
GO:0030165 PDZ domain binding
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001662 behavioral fear response
GO:0006810 transport
GO:0006874 cellular calcium ion homeostasis
GO:0006886 intracellular protein transport
GO:0007165 signal transduction
GO:0007215 glutamate receptor signaling pathway
GO:0007268 synaptic transmission
GO:0019228 neuronal action potential
GO:0034220 ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0043113 receptor clustering
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0046328 regulation of JNK cascade
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0050804 regulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0051402 neuron apoptotic process
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060080 regulation of inhibitory postsynaptic membrane potential
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008328 ionotropic glutamate receptor complex
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0032839 dendrite cytoplasm
GO:0032983 kainate selective glutamate receptor complex
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Neuronal System pathway
Ionotropic activity of Kainate Receptors pathway
Activation of Kainate Receptors upon glutamate binding pathway
Transmission across Chemical Synapses pathway
Activation of Na-permeable Kainate Receptors pathway
Activation of Ca-permeable Kainate Receptor pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
Neuroactive ligand-receptor interaction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.605579 Hs.98262
RefSeq NM_001166247 NM_021956 NM_175768 XM_005266945 XM_005266946 XM_006715465
HUGO
OMIM
CCDS CCDS5048 CCDS5049 CCDS55045
HPRD 00692
IMGT
EMBL
GenPept
RNA Seq Atlas