Homo sapiens Gene: MAN1A1
Summary
InnateDB Gene IDBG-95959.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAN1A1
Gene Name mannosidase, alpha, class 1A, member 1
Synonyms HUMM3; HUMM9; MAN9
Species Homo sapiens
Ensembl Gene ENSG00000111885
Encoded Proteins
mannosidase, alpha, class 1A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:119177209-119349761
Strand Reverse strand
Band q22.31
Transcripts
ENST00000368468 ENSP00000357453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
GO:0015923 mannosidase activity
Biological Process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
N-glycan trimming and elongation in the cis-Golgi pathway
Transport to the Golgi and subsequent modification pathway
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
Metabolism of proteins pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P33908
TrEMBL
UniProt Splice Variant
Entrez Gene 4121
UniGene Hs.102788 Hs.611797
RefSeq NM_005907 XM_005266986
HUGO HGNC:6821
OMIM 604344
CCDS CCDS5122
HPRD
IMGT
EMBL AL022722 AL078600 X74837
GenPept CAA52831 CAB75695 CAI20315
RNA Seq Atlas 4121