Version 5.4
Homo sapiens Gene: MAN1A1
Summary
InnateDB Gene IDBG-95959.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAN1A1
Gene Name mannosidase, alpha, class 1A, member 1
Synonyms HUMM3; HUMM9; MAN9
Species Homo sapiens
Ensembl Gene ENSG00000111885
Encoded Proteins
IDBP-95961
mannosidase, alpha, class 1A, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:119177209-119349761
Strand Reverse strand
Band q22.31
Transcripts
ENST00000368468 ENSP00000357453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
GO:0015923 mannosidase activity
Biological Process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003746
View Gene Order
ENSBTAG00000024381
Not yet available
Pathways
NETPATH
REACTOME
REACT_25396
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
REACT_25210
N-glycan trimming and elongation in the cis-Golgi pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P33908
TrEMBL
UniProt Splice Variant
Entrez Gene 4121
UniGene Hs.102788 Hs.611797
RefSeq NM_005907 XM_005266986
HUGO HGNC:6821
OMIM 604344
CCDS CCDS5122
HPRD
IMGT
EMBL AL022722 AL078600 X74837
GenPept CAA52831 CAB75695 CAI20315
RNA Seq Atlas 4121

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca