Mus musculus Gene: Man1a
Summary
InnateDB Gene IDBG-151744.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Man1a
Gene Name mannosidase 1, alpha
Synonyms Man1a1; PCR1
Species Mus musculus
Ensembl Gene ENSMUSG00000003746
Encoded Proteins
mannosidase 1, alpha
mannosidase 1, alpha
mannosidase 1, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111885:
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:53904788-54075796
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000003843 ENSMUSP00000003843
ENSMUST00000105470 ENSMUSP00000101110
ENSMUST00000105469 ENSMUSP00000101109
ENSMUST00000146483
ENSMUST00000133330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0008152 metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Transport to the Golgi and subsequent modification pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Asparagine N-linked glycosylation pathway
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
N-glycan trimming and elongation in the cis-Golgi pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 pathway
N-glycan trimming and elongation in the cis-Golgi pathway
Transport to the Golgi and subsequent modification pathway
Asparagine N-linked glycosylation pathway
Post-translational protein modification pathway
Metabolism of proteins pathway
KEGG
N-Glycan biosynthesis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P45700
TrEMBL Q544T7
UniProt Splice Variant
Entrez Gene 17155
UniGene Mm.117294 Mm.399665 Mm.408047
RefSeq NM_008548 XM_006512568 XM_006512569
OMIM
CCDS CCDS23848
HPRD
IMGT
MGI ID MGI:104677
MGI Symbol Man1a
EMBL AK031038 AK154820 BC015265 CH466540 U04299
GenPept AAA17747 AAH15265 BAC27225 BAE32852 EDL05098 EDL05100
RNA Seq Atlas 17155