Version 5.4
Homo sapiens Gene: FUT8
Summary
InnateDB Gene IDBG-9620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUT8
Gene Name fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000033170
Encoded Proteins
IDBP-9622
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-9624
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-9626
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-241268
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-596318
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-589199
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-584559
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-598602
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-590844
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-597952
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
IDBP-597795
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:65410592-65744121
Strand Forward strand
Band q23.3
Transcripts
ENST00000360689 ENSP00000353910
ENST00000342677 ENSP00000345865
ENST00000358307 ENSP00000351057
ENST00000394586 ENSP00000378087
ENST00000556518 ENSP00000452597
ENST00000557164 ENSP00000452433
ENST00000549235
ENST00000555559 ENSP00000451689
ENST00000553924 ENSP00000451577
ENST00000557338 ENSP00000452105
ENST00000554610 ENSP00000452309
ENST00000556292
ENST00000554667 ENSP00000452147
ENST00000557536
ENST00000554765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0017124 SH3 domain binding
GO:0046921 alpha-(1->6)-fucosyltransferase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006487 protein N-linked glycosylation
GO:0006491 N-glycan processing
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007585 respiratory gaseous exchange
GO:0008152 metabolic process
GO:0009312 oligosaccharide biosynthetic process
GO:0016477 cell migration
GO:0018279 protein N-linked glycosylation via asparagine
GO:0033578 protein glycosylation in Golgi
GO:0036065 fucosylation
GO:0036071 N-glycan fucosylation
GO:0042355 L-fucose catabolic process
GO:0043112 receptor metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0046368 GDP-L-fucose metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021065
View Gene Order
ENSBTAG00000019819
Not yet available
Pathways
NETPATH
REACTOME
REACT_25302
Reactions specific to the complex N-glycan synthesis pathway pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa00533
Glycosaminoglycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.597649 Hs.627697
RefSeq NM_004480 NM_178155 NM_178156 XM_006720096
HUGO
OMIM
CCDS CCDS9775 CCDS9776
HPRD 03994
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca