Version 5.4
Homo sapiens Gene: MED23
Summary
InnateDB Gene IDBG-96537.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED23
Gene Name mediator complex subunit 23
Synonyms ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR-2; SUR2
Species Homo sapiens
Ensembl Gene ENSG00000112282
Encoded Proteins
IDBP-96539
mediator complex subunit 23
IDBP-96541
mediator complex subunit 23
IDBP-96545
mediator complex subunit 23
IDBP-96547
mediator complex subunit 23
IDBP-96549
mediator complex subunit 23
IDBP-593366
mediator complex subunit 23
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:131573966-131628229
Strand Reverse strand
Band q23.2
Transcripts
ENST00000354577 ENSP00000346588
ENST00000368068 ENSP00000357047
ENST00000368060 ENSP00000357039
ENST00000368058 ENSP00000357037
ENST00000368053 ENSP00000357032
ENST00000479213
ENST00000484885
ENST00000489888
ENST00000539158 ENSP00000445072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 67 [view]
Protein-Protein 64 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
Cellular Component
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019984
View Gene Order
ENSBTAG00000012418
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9ULK4
TrEMBL B9TX51
UniProt Splice Variant
Entrez Gene 9439
UniGene Hs.29679 Hs.595435
RefSeq NM_001270522 NM_001270521 NM_004830 NM_015979 XM_005267223 XM_006715612
HUGO HGNC:2372
OMIM 605042
CCDS CCDS59039 CCDS5146 CCDS5147
HPRD 05436
IMGT
EMBL AB033042 AF104255 AF105332 AF135022 AL121575 AL136776 BC060759 CH471051 EU392522 EU392526 EU392532
GenPept AAD12724 AAD30202 AAD31729 AAH60759 ACB88850 ACB88854 ACB88860 BAA86530 CAB66710 CAB92072 CAB92073 CAI23319 CAI23320 EAW48052
RNA Seq Atlas 9439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca