Version 5.4
| Homo sapiens Gene: SLC18A1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-9668.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SLC18A1 | ||||||||||||||||||
| Gene Name | solute carrier family 18 (vesicular monoamine), member 1 | ||||||||||||||||||
| Synonyms | CGAT; VAT1; VMAT1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000036565 | ||||||||||||||||||
| Encoded Proteins |
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
solute carrier family 18 (vesicular monoamine), member 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:20144855-20183206 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p21.3 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Na+/Cl- dependent neurotransmitter transporters pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
Transmembrane transport of small molecules pathway
SLC-mediated transmembrane transport pathway
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| KEGG |
Parkinson's disease pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P54219 | ||||||||||||||||||
| TrEMBL | E5RK12 Q96GL6 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 6570 | ||||||||||||||||||
| UniGene | Hs.158322 | ||||||||||||||||||
| RefSeq | NM_001135691 NM_001142324 NM_001142325 NM_003053 | ||||||||||||||||||
| HUGO | HGNC:10934 | ||||||||||||||||||
| OMIM | 193002 | ||||||||||||||||||
| CCDS | CCDS47814 CCDS47815 CCDS6013 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC025853 BC006317 BC009387 U39905 | ||||||||||||||||||
| GenPept | AAC50472 AAH06317 AAH09387 | ||||||||||||||||||
| RNA Seq Atlas | 6570 | ||||||||||||||||||