Homo sapiens Gene: DAB1
Summary
InnateDB Gene IDBG-99165.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DAB1
Gene Name disabled homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173406
Encoded Proteins
disabled homolog 1 (Drosophila)
disabled homolog 1 (Drosophila)
disabled homolog 1 (Drosophila)
disabled homolog 1 (Drosophila)
disabled homolog 1 (Drosophila)
disabled homolog 1 (Drosophila)
disabled homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:56994778-58546734
Strand Reverse strand
Band p32.1
Transcripts
ENST00000371236 ENSP00000360280
ENST00000332102 ENSP00000329120
ENST00000371232 ENSP00000360276
ENST00000371231 ENSP00000360275
ENST00000371230 ENSP00000360274
ENST00000420954 ENSP00000395296
ENST00000414851 ENSP00000387581
ENST00000485760
ENST00000489267
ENST00000473821
ENST00000477280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
Biological Process
GO:0001764 neuron migration
GO:0007162 negative regulation of cell adhesion
GO:0007264 small GTPase mediated signal transduction
GO:0007420 brain development
GO:0007494 midgut development
GO:0007628 adult walking behavior
GO:0016358 dendrite development
GO:0021517 ventral spinal cord development
GO:0021589 cerebellum structural organization
GO:0021795 cerebral cortex cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
GO:0021942 radial glia guided migration of Purkinje cell
GO:0021987 cerebral cortex development
GO:0042493 response to drug
GO:0045666 positive regulation of neuron differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0046426 negative regulation of JAK-STAT cascade
GO:0048712 negative regulation of astrocyte differentiation
GO:0050771 negative regulation of axonogenesis
GO:0051645 Golgi localization
GO:0097477 lateral motor column neuron migration
Cellular Component
GO:0005829 cytosol
GO:0005903 brush border
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Reelin signaling pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL Q8NFD0
UniProt Splice Variant
Entrez Gene 1600
UniGene Hs.477370 Hs.595239
RefSeq NM_021080
HUGO HGNC:2661
OMIM 603448
CCDS CCDS607
HPRD 04582
IMGT
EMBL AF525763
GenPept AAM83107
RNA Seq Atlas 1600