Version 5.4
Homo sapiens Gene: GNG12
Summary
InnateDB Gene IDBG-99585.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNG12
Gene Name guanine nucleotide binding protein (G protein), gamma 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172380
Encoded Proteins
IDBP-99587
guanine nucleotide binding protein (G protein), gamma 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:67701466-67833467
Strand Reverse strand
Band p31.3
Transcripts
ENST00000370982 ENSP00000360021
ENST00000494936
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0030165 PDZ domain binding
GO:0042301 phosphate ion binding
Biological Process
GO:0006112 energy reserve metabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007268 synaptic transmission
GO:0021987 cerebral cortex development
GO:0032496 response to lipopolysaccharide
GO:0044281 small molecule metabolic process
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036402
View Gene Order
ENSBTAG00000035697
Not yet available
Pathways
NETPATH
REACTOME
REACT_23946
Prostacyclin signalling through prostacyclin receptor pathway
REACT_23876
Platelet homeostasis pathway
REACT_20653
ADP signalling through P2Y purinoceptor 12 pathway
REACT_19140
ADP signalling through P2Y purinoceptor 1 pathway
REACT_20647
Thromboxane signalling through TP receptor pathway
REACT_21384
Thrombin signalling through proteinase activated receptors (PARs) pathway
REACT_24023
Vasopressin regulates renal water homeostasis via Aquaporins pathway
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19231
G alpha (i) signalling events pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_19145
G beta:gamma signalling through PLC beta pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_19327
G alpha (s) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_18377
Glucagon-type ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_25004
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
REACT_25031
GABA B receptor activation pathway
REACT_21254
Presynaptic function of Kainate receptors pathway
REACT_75831
Activation of G protein gated Potassium channels pathway
REACT_18274
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
REACT_18339
Adrenaline,noradrenaline inhibits insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1665
Glucagon signaling in metabolic regulation pathway
REACT_1505
Integration of energy metabolism pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_172761
Ca2+ pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_14797
Signaling by GPCR pathway
REACT_25199
GABA receptor activation pathway
REACT_75780
G protein gated Potassium channels pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_25330
Activation of GABAB receptors pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_75918
Inwardly rectifying K+ channels pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_75908
Potassium Channels pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21340
GPCR ligand binding pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_20524
Signal amplification pathway
REACT_23887
Aquaporin-mediated transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q9UBI6
TrEMBL
UniProt Splice Variant
Entrez Gene 55970
UniGene Hs.431101
RefSeq NM_018841
HUGO HGNC:19663
OMIM 615405
CCDS CCDS30749
HPRD
IMGT
EMBL AF119663 AF123766 AF188181 AF365871 AF493879 AK293101 AL832431 BC005940 CH471059
GenPept AAF04571 AAF17220 AAH05940 AAK53385 AAM12593 AAP97245 BAF85790 CAH10645 EAX06484 EAX06485 EAX06486
RNA Seq Atlas 55970

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca