Version 5.4
| Mus musculus Gene: Bcar3 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-191667.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Bcar3 | ||||||||
| Gene Name | breast cancer anti-estrogen resistance 3 | ||||||||
| Synonyms | AI131758; AND-34 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000028121 | ||||||||
| Encoded Proteins |
breast cancer anti-estrogen resistance 3
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137936:
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 3:122419780-122530180 | ||||||||
| Strand | Forward strand | ||||||||
| Band | G1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
EGFR1 pathway
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| REACTOME | |||||||||
| KEGG | |||||||||
| INOH | |||||||||
| PID NCI |
Regulation of CDC42 activity
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| Cross-References | |||||||||
| SwissProt | Q9QZK2 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 29815 | ||||||||
| UniGene | Mm.398478 Mm.45815 | ||||||||
| RefSeq | NM_013867 XM_006501557 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17810 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:1352501 | ||||||||
| MGI Symbol | Bcar3 | ||||||||
| EMBL | AF179566 AK143894 AK165396 BC023930 | ||||||||
| GenPept | AAD53182 AAH23930 BAE25587 BAE38160 | ||||||||
| RNA Seq Atlas | 29815 | ||||||||