InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.41831

Summary

InnateDB Gene

IDBG-634810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.41831

Gene Name

homeodomain-interacting protein kinase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011322

Encoded Proteins

IDBP-686620

homeodomain-interacting protein kinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163349:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:29512758-29563150

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015051

ENSBTAP00000015051

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007224	smoothened signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0009952	anterior/posterior pattern specification
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842	retina layer formation
GO:0016926	protein desumoylation
GO:0030182	neuron differentiation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0048596	embryonic camera-type eye morphogenesis
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:0060235	lens induction in camera-type eye
GO:0061072	iris morphogenesis
GO:0072577	endothelial cell apoptotic process
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016605	PML body
GO:0016607	nuclear speck

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000163349

View Gene Order

ENSMUSG00000008730

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118713

YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway

REACT_12627

Generic Transcription Pathway pathway

REACT_71

Gene Expression pathway

REACT_233572

Gene Expression pathway

REACT_196516

YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway

REACT_206529

Generic Transcription Pathway pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BQ34

UniProt Splice Variant

Entrez Gene

512233

UniGene

Bt.41831

RefSeq

NM_001109998 XM_005204016 XM_005204017 XM_005204018 XM_005204021 XM_005204022

HUGO

HGNC:19006

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02007473 DAAA02007474 DAAA02007475

GenPept

RNA Seq Atlas

512233