Version 5.4
Homo sapiens Gene: SMOC1
Summary
InnateDB Gene IDBG-10556.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMOC1
Gene Name SPARC related modular calcium binding 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198732
Encoded Proteins
IDBP-10558
SPARC related modular calcium binding 1
IDBP-10560
SPARC related modular calcium binding 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:69854131-70032366
Strand Forward strand
Band q24.2
Transcripts
ENST00000361956 ENSP00000355110
ENST00000381280 ENSP00000370680
ENST00000555917
ENST00000553839
ENST00000557483
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050840 extracellular matrix binding
Biological Process
GO:0001654 eye development
GO:0007165 signal transduction
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030154 cell differentiation
GO:0030198 extracellular matrix organization
GO:0045667 regulation of osteoblast differentiation
GO:0060173 limb development
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021136
View Gene Order
ENSBTAG00000030599
Not yet available
Cross-References
SwissProt Q9H4F8
TrEMBL A0A024R6E0
UniProt Splice Variant
Entrez Gene 64093
UniGene Hs.497349 Hs.607808
RefSeq NM_022137 NM_001034852
HUGO HGNC:20318
OMIM 608488
CCDS CCDS9798 CCDS32110
HPRD 12244
IMGT
EMBL AJ249900 AK289988 AK313063 AL135747 AL157789 BC008608 BC011548 CH471061
GenPept AAH08608 AAH11548 BAF82677 BAG35892 CAC10352 EAW81013 EAW81014 EAW81015
RNA Seq Atlas 64093

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca