Version 5.4
Homo sapiens Gene: LHX9
Summary
InnateDB Gene IDBG-105584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX9
Gene Name LIM homeobox 9
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000143355
Encoded Proteins
IDBP-105586
LIM homeobox 9
IDBP-105588
LIM homeobox 9
IDBP-105590
LIM homeobox 9
IDBP-105592
LIM homeobox 9
IDBP-807834
LIM homeobox 9
IDBP-594466
LIM homeobox 9
IDBP-807833
LIM homeobox 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:197911902-197935478
Strand Forward strand
Band q31.3
Transcripts
ENST00000367391 ENSP00000356361
ENST00000367390 ENSP00000356360
ENST00000367388 ENSP00000356358
ENST00000367387 ENSP00000356357
ENST00000475727 ENSP00000482898
ENST00000561173 ENSP00000453064
ENST00000606127 ENSP00000483170
ENST00000615520
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0008045 motor neuron axon guidance
GO:0008283 cell proliferation
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0035262 gonad morphogenesis
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019230
View Gene Order
ENSBTAG00000013499
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001014434 NM_020204 XM_005245349
HUGO
OMIM
CCDS CCDS1393 CCDS30962
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca