InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EXO1

Summary

InnateDB Gene

IDBG-107718.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXO1

Gene Name

exonuclease 1

Synonyms

HEX1; hExoI

Species

Homo sapiens

Ensembl Gene

ENSG00000174371

Encoded Proteins

IDBP-107720

exonuclease 1

IDBP-107722

exonuclease 1

IDBP-390189

exonuclease 1

IDBP-390192

exonuclease 1

IDBP-390193

exonuclease 1

IDBP-475491

exonuclease 1

IDBP-484995

exonuclease 1

IDBP-475473

exonuclease 1

IDBP-475867

exonuclease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a protein with 5\' to 3\' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:241847967-241895148

Strand

Forward strand

Band

q43

Transcripts

ENST00000366548	ENSP00000355506
ENST00000348581	ENSP00000311873
ENST00000423131	ENSP00000415531
ENST00000437497	ENSP00000412041
ENST00000450748	ENSP00000406652
ENST00000519225	ENSP00000429720
ENST00000523590	ENSP00000430082
ENST00000518483	ENSP00000430251
ENST00000493702
ENST00000469419
ENST00000521202	ENSP00000428326
ENST00000518741

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	30 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004523	RNA-DNA hybrid ribonuclease activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0035312	5'-3' exodeoxyribonuclease activity
GO:0043566	structure-specific DNA binding
GO:0045145	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO:0046872	metal ion binding
GO:0048256	flap endonuclease activity
GO:0051908	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006310	DNA recombination
GO:0007126	meiotic nuclear division
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0045190	isotype switching
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039748

View Gene Order

ENSBTAG00000009396

Not yet available

Pathways

NETPATH

REACTOME

REACT_228145

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway

REACT_228019

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway

REACT_228013

Mismatch Repair pathway

REACT_216

DNA Repair pathway

KEGG

hsa03430

Mismatch repair pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.498248

RefSeq

NM_003686 NM_006027 NM_130398 XM_005273350 XM_006711840

HUGO

OMIM

CCDS

CCDS1620 CCDS44336

HPRD

06932

IMGT

EMBL

GenPept

RNA Seq Atlas