InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Colec12

Summary

InnateDB Gene

IDBG-128247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Colec12

Gene Name

collectin sub-family member 12

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036103

Encoded Proteins

IDBP-128249

collectin sub-family member 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26290605

[Homo sapiens] Soluble COLEC12 can recognize Aspergillus fumigatus leading to activation of the alternative pathway of complement.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158270:
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:9707648-9877995

Strand

Forward strand

Band

Transcripts

ENSMUST00000040069

ENSMUSP00000043220

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008329	signaling pattern recognition receptor activity
GO:0030169	low-density lipoprotein particle binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0006910	phagocytosis, recognition
GO:0006955	immune response

Cellular Component

GO:0005581	collagen trimer
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000158270

View Gene Order

ENSBTAG00000007705

Not yet available

Pathways

NETPATH

REACTOME

REACT_196573

Binding and Uptake of Ligands by Scavenger Receptors pathway

REACT_196581

Scavenging by Class A Receptors pathway

KEGG

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

REACT_163699

Scavenging by Class A Receptors pathway

REACT_209041

Scavenging by Class A Receptors pathway

REACT_213817

Binding and Uptake of Ligands by Scavenger Receptors pathway

KEGG

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

Q8K4Q8

TrEMBL

UniProt Splice Variant

Entrez Gene

140792

UniGene

Mm.218571 Mm.419536

RefSeq

NM_130449 XM_006525640

OMIM

CCDS

CCDS37732

HPRD

IMGT

MGI ID

MGI:2152907

MGI Symbol

Colec12

EMBL

AB038519 AB078434 AK042772 AK158366 BC057936

GenPept

AAH57936 BAB82497 BAC05523 BAC31361 BAE34474

RNA Seq Atlas

140792