InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ODC1

Summary

InnateDB Gene

IDBG-638199.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODC1

Gene Name

Ornithine decarboxylase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004256

Encoded Proteins

IDBP-690253

Ornithine decarboxylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115758:
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:87178098-87182503

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005575

ENSBTAP00000005575

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004586	ornithine decarboxylase activity
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001822	kidney development
GO:0006596	polyamine biosynthetic process
GO:0008284	positive regulation of cell proliferation
GO:0033387	putrescine biosynthetic process from ornithine
GO:0042176	regulation of protein catabolic process