InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Suv39h1

Summary

InnateDB Gene

IDBG-130058.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suv39h1

Gene Name

suppressor of variegation 3-9 homolog 1 (Drosophila)

Synonyms

AI852103; AL022883; DXHXS7466e; H3-K9-HMTase 1; KMT1A; mIS6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039231

Encoded Proteins

IDBP-249200

suppressor of variegation 3-9 homolog 1 (Drosophila)

IDBP-249202

suppressor of variegation 3-9 homolog 1 (Drosophila)

IDBP-249204

suppressor of variegation 3-9 homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101945:
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq, Jul 2008]
This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:8061171-8074760

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000115638	ENSMUSP00000111301
ENSMUST00000115637	ENSMUSP00000111300
ENSMUST00000115636	ENSMUSP00000111299
ENSMUST00000150095
ENSMUST00000127617

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0008276	protein methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0046974	histone methyltransferase activity (H3-K9 specific)
GO:0047485	protein N-terminus binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006323	DNA packaging
GO:0006342	chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006364	rRNA processing
GO:0007049	cell cycle
GO:0030154	cell differentiation
GO:0034968	histone lysine methylation
GO:0036123	histone H3-K9 dimethylation
GO:0036124	histone H3-K9 trimethylation
GO:0042754	negative regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051567	histone H3-K9 methylation

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005654	nucleoplasm
GO:0005677	chromatin silencing complex
GO:0005720	nuclear heterochromatin
GO:0033553	rDNA heterochromatin