InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBXL7

Summary

InnateDB Gene

IDBG-13191.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXL7

Gene Name

F-box and leucine-rich repeat protein 7

Synonyms

FBL6; FBL7

Species

Homo sapiens

Ensembl Gene

ENSG00000183580

Encoded Proteins

IDBP-13193

F-box and leucine-rich repeat protein 7

IDBP-477145

F-box and leucine-rich repeat protein 7

IDBP-481580

F-box and leucine-rich repeat protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. [provided by RefSeq, Jul 2008]
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:15500196-15939795

Strand

Forward strand

Band

p15.1

Transcripts

ENST00000329673	ENSP00000329632
ENST00000504595	ENSP00000423630
ENST00000510662	ENSP00000425184

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0019005	SCF ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000043556

View Gene Order

ENSBTAG00000003219

Not yet available

Cross-References

SwissProt

Q9UJT9

TrEMBL

J3KNM9

UniProt Splice Variant

Entrez Gene

23194

UniGene

Hs.433057 Hs.596142 Hs.617802

RefSeq

NM_001278317 NM_012304 XM_005248273

HUGO

HGNC:13604

OMIM

605656

CCDS

CCDS54833 CCDS64129

HPRD

IMGT

EMBL

AB020647 AC010477 AC010638 AC027332 AC091872 AC091970 AF174593 AF199356 BC075061 BC136424 CH471102

GenPept

AAF04514 AAF09248 AAH75061 AAI36425 BAA74863 EAX08029

RNA Seq Atlas

23194