InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Uba1

Summary

InnateDB Gene

IDBG-134806.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uba1

Gene Name

ubiquitin-like modifier activating enzyme 1

Synonyms

A1S9; Sbx; Ube-1; Ube1x

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001924

Encoded Proteins

IDBP-134808

ubiquitin-like modifier activating enzyme 1

IDBP-134810

ubiquitin-like modifier activating enzyme 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:20658326-20683179

Strand

Forward strand

Band

A1.3

Transcripts

ENSMUST00000001989	ENSMUSP00000001989
ENSMUST00000089217	ENSMUSP00000086626
ENSMUST00000152235
ENSMUST00000130694
ENSMUST00000137892
ENSMUST00000136915

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006464	cellular protein modification process
GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005765	lysosomal membrane
GO:0010008	endosome membrane
GO:0030057	desmosome
GO:0030867	rough endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome