Version 5.4
Mus musculus Gene: Taf3
Summary
InnateDB Gene IDBG-135430.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Taf3
Gene Name TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000025782
Encoded Proteins
IDBP-135432
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
IDBP-250774
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
IDBP-250776
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
IDBP-250778
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165632:
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:9914552-10048596
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000026888 ENSMUSP00000026888
ENSMUST00000114909 ENSMUSP00000110559
ENSMUST00000114907 ENSMUSP00000110557
ENSMUST00000114906 ENSMUSP00000110556
ENSMUST00000129720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0051457 maintenance of protein location in nucleus
Cellular Component
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165632
View Gene Order
ENSBTAG00000002836
Not yet available
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_233572
Gene Expression pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03022
Basal transcription factors pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6256
HIV Life Cycle pathway
REACT_6185
HIV Infection pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
KEGG
hsa03022
Basal transcription factors pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.86343
RefSeq NM_027748
OMIM
CCDS CCDS15675
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca