InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prkdc

Summary

InnateDB Gene

IDBG-135771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prkdc

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

AI326420; AU019811; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; dxnph; HYRC1; p460; scid; slip; XRCC7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022672

Encoded Proteins

IDBP-135773

protein kinase, DNA activated, catalytic polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24098118

[Homo sapiens] Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblast.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000253729:
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:15637866-15842235

Strand

Forward strand

Band

Transcripts

ENSMUST00000023352	ENSMUSP00000023352
ENSMUST00000182134

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 213 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	213 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004677	DNA-dependent protein kinase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0001756	somitogenesis
GO:0001933	negative regulation of protein phosphorylation
GO:0002326	B cell lineage commitment
GO:0002328	pro-B cell differentiation
GO:0002360	T cell lineage commitment
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0007420	brain development
GO:0007507	heart development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332	response to gamma radiation
GO:0018105	peptidyl-serine phosphorylation
GO:0030098	lymphocyte differentiation
GO:0031648	protein destabilization
GO:0032869	cellular response to insulin stimulus
GO:0033077	T cell differentiation in thymus
GO:0033152	immunoglobulin V(D)J recombination
GO:0033153	T cell receptor V(D)J recombination
GO:0035234	ectopic germ cell programmed cell death
GO:0042752	regulation of circadian rhythm
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072431	signal transduction involved in mitotic G1 DNA damage checkpoint

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0016020	membrane
GO:0070419	nonhomologous end joining complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000253729

View Gene Order

ENSBTAG00000017019

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_238355

Double-Strand Break Repair pathway

REACT_230745

Immune System pathway

REACT_254501

Nonhomologous End-joining (NHEJ) pathway

REACT_233397

DNA Repair pathway

REACT_196447

IRF3-mediated induction of type I IFN pathway

REACT_218897

Cytosolic sensors of pathogen-associated DNA pathway

REACT_196457

STING mediated induction of host immune responses pathway

REACT_224809

Processing of DNA ends prior to end rejoining pathway

KEGG

mmu04110

Cell cycle pathway

mmu03450

Non-homologous end-joining pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_147841

STING mediated induction of host immune responses pathway

REACT_1201

Processing of DNA ends prior to end rejoining pathway

REACT_1022

Nonhomologous End-joining (NHEJ) pathway

REACT_163993

IRF3-mediated induction of type I IFN pathway

REACT_6802

Innate Immune System pathway

REACT_2054

Double-Strand Break Repair pathway

REACT_6900

Immune System pathway

REACT_118823

Cytosolic sensors of pathogen-associated DNA pathway

REACT_216

DNA Repair pathway

KEGG

hsa04110

Cell cycle pathway

hsa03450

Non-homologous end-joining pathway

INOH

PID NCI

pi3kciaktpathway

Class I PI3K signaling events mediated by Akt

ar_pathway

Coregulation of Androgen receptor activity

bard1pathway

BARD1 signaling events

dnapk_pathway

DNA-PK pathway in nonhomologous end joining

Cross-References

SwissProt

P97313

TrEMBL

Q91UZ3

UniProt Splice Variant

Entrez Gene

19090

UniGene

Mm.71

RefSeq

NM_011159 XM_006521859 XM_006521860 XM_006521861 XM_006521862

OMIM

CCDS

CCDS27978

HPRD

IMGT

MGI ID

MGI:104779

MGI Symbol

Prkdc

EMBL

AB000629 AB007544 AB011543 AB030754 AC111103 AC154586 AJ315660 AJ315661 AK084827 AK088981 CT010522 CT030649 D83786 D87521 DQ235257 DQ235258 U78157 U78158

GenPept

AAB36939 AAB36940 ABB36568 ABB36569 BAA12115 BAA19566 BAA28873 BAA28875 BAA34640 BAB91149 BAC40685 BAE43387 CAC42770 CAC42771

RNA Seq Atlas

19090