Version 5.4
Mus musculus Gene: Pclo
Summary
InnateDB Gene IDBG-135873.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pclo
Gene Name piccolo (presynaptic cytomatrix protein)
Synonyms Acz; Pico
Species Mus musculus
Ensembl Gene ENSMUSG00000061601
Encoded Proteins
IDBP-135875
piccolo (presynaptic cytomatrix protein)
IDBP-788412
piccolo (presynaptic cytomatrix protein)
IDBP-788413
piccolo (presynaptic cytomatrix protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186472:
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:14514918-14860184
Strand Forward strand
Band A1
Transcripts
ENSMUST00000030691 ENSMUSP00000030691
ENSMUST00000182407 ENSMUSP00000138419
ENSMUST00000182426
ENSMUST00000182915 ENSMUSP00000138607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005522 profilin binding
GO:0005544 calcium-dependent phospholipid binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0008152 metabolic process
GO:0016080 synaptic vesicle targeting
GO:0017157 regulation of exocytosis
GO:0019933 cAMP-mediated signaling
GO:0030073 insulin secretion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0030054 cell junction
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186472
View Gene Order
ENSBTAG00000017350
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.146275 Mm.470742 Mm.471072
RefSeq NM_001110796 NM_011995 XM_006503583 XM_006503586
OMIM
CCDS CCDS51415 CCDS59667
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca