InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trim24

Summary

InnateDB Gene

IDBG-136387.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim24

Gene Name

tripartite motif-containing 24

Synonyms

A130082H20Rik; AI447469; D430004I05Rik; TIF1; TIF1-alpha; Tif1a; TIF1alpha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029833

Encoded Proteins

IDBP-136389

tripartite motif-containing 24

IDBP-401483

tripartite motif-containing 24

IDBP-401482

tripartite motif-containing 24

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM24 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

The protein encoded by this gene is part of the tripartite-motif containing family (TRIM), which are typified by the RING, B-box type 1, B-box type 2, and coiled-coil region domains. This protein, which also contains a PHD/TTC finger and bromodomain important for regulating nuclear receptors and binding chromatin, has important roles in differentiation, development, and tissue homeostasis. This protein has been reported to regulate the activity of the tumor suppressor p53 and of the retinoic acid receptor. A translocation event between this gene and Braf transforming gene, which results in the fusion protein T18, has been reported in hepatocellular carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:37870811-37966296

Strand

Forward strand

Band

Transcripts

ENSMUST00000031859	ENSMUSP00000031859
ENSMUST00000120428	ENSMUSP00000113063
ENSMUST00000120238	ENSMUSP00000114001
ENSMUST00000153004
ENSMUST00000149828
ENSMUST00000149561
ENSMUST00000123007
ENSMUST00000135387

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0016922	ligand-dependent nuclear receptor binding
GO:0034056	estrogen response element binding
GO:0043565	sequence-specific DNA binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0031647	regulation of protein stability
GO:0042981	regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046777	protein autophosphorylation
GO:0055074	calcium ion homeostasis
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0071391	cellular response to estrogen stimulus
GO:1901796	regulation of signal transduction by p53 class mediator