InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRIM24

Summary

InnateDB Gene

IDBG-635873.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM24

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002431

Encoded Proteins

IDBP-687793

tripartite motif containing 24

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23438823

[Homo sapiens] TRIM24 was identified in a systematic screen for positive regulators of innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122779:
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:102977535-103090730

Strand

Forward strand

Band

Transcripts

ENSBTAT00000003151

ENSBTAP00000003151

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004672	protein kinase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0034056	estrogen response element binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006468	protein phosphorylation
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0030163	protein catabolic process
GO:0031647	regulation of protein stability
GO:0042981	regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046777	protein autophosphorylation
GO:0055074	calcium ion homeostasis
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0071391	cellular response to estrogen stimulus
GO:1901796	regulation of signal transduction by p53 class mediator