Version 5.4
Mus musculus Gene: Ube2r2
Summary
InnateDB Gene IDBG-137399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2r2
Gene Name ubiquitin-conjugating enzyme E2R 2
Synonyms 1200003M11Rik; Cdc34b; Ubc3b
Species Mus musculus
Ensembl Gene ENSMUSG00000036241
Encoded Proteins
IDBP-137401
ubiquitin-conjugating enzyme E2R 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107341:
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:41135743-41193380
Strand Forward strand
Band A5
Transcripts
ENSMUST00000040008 ENSMUSP00000038813
ENSMUST00000129874
ENSMUST00000123642
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006513 protein monoubiquitination
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0005575 cellular_component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107341
View Gene Order
ENSBTAG00000000693
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt Q6ZWZ2
TrEMBL
UniProt Splice Variant
Entrez Gene 67615
UniGene Mm.389540
RefSeq NM_026275
OMIM
CCDS CCDS18057
HPRD
IMGT
MGI ID MGI:1914865
MGI Symbol Ube2r2
EMBL AJ240086 AK003550 AK007517 AK075703 AK075714 AL807823 AL954379 BC011112
GenPept AAH11112 BAB22850 BAB25085 BAC35899 BAC35904 CAC80335 CAM20979 CAM27658
RNA Seq Atlas 67615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca