InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trpc4

Summary

InnateDB Gene

IDBG-144332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpc4

Gene Name

transient receptor potential cation channel, subfamily C, member 4

Synonyms

CCE1; STRPC4; Trp4; Trrp4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027748

Encoded Proteins

IDBP-144334

transient receptor potential cation channel, subfamily C, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133107:
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:54156057-54318470

Strand

Forward strand

Band

Transcripts

ENSMUST00000029311

ENSMUSP00000029311

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0015279	store-operated calcium channel activity
GO:0045296	cadherin binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0014051	gamma-aminobutyric acid secretion
GO:0048709	oligodendrocyte differentiation
GO:0055085	transmembrane transport
GO:0070509	calcium ion import

Cellular Component

GO:0005886	plasma membrane
GO:0005901	caveola
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030863	cortical cytoskeleton
GO:0034704	calcium channel complex
GO:0043234	protein complex
GO:0045121	membrane raft