Version 5.4
Mus musculus Gene: Lig1
Summary
InnateDB Gene IDBG-144442.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lig1
Gene Name ligase I, DNA, ATP-dependent
Synonyms AL033288; LigI
Species Mus musculus
Ensembl Gene ENSMUSG00000056394
Encoded Proteins
IDBP-144446
ligase I, DNA, ATP-dependent
IDBP-533020
ligase I, DNA, ATP-dependent
IDBP-537835
ligase I, DNA, ATP-dependent
IDBP-621887
ligase I, DNA, ATP-dependent
IDBP-722422
IDBP-788648
ligase I, DNA, ATP-dependent
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105486:
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:13277283-13311433
Strand Forward strand
Band A1
Transcripts
ENSMUST00000098814 ENSMUSP00000096411
ENSMUST00000148471
ENSMUST00000156525
ENSMUST00000146998 ENSMUSP00000121102
ENSMUST00000123846
ENSMUST00000147735
ENSMUST00000123025 ENSMUSP00000114872
ENSMUST00000138453
ENSMUST00000131294
ENSMUST00000165964 ENSMUSP00000126525
ENSMUST00000177588 ENSMUSP00000136972
ENSMUST00000185145 ENSMUSP00000138907
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0042542 response to hydrogen peroxide
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105486
View Gene Order
ENSBTAG00000014595
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu03030
DNA replication pathway
mmu03420
Nucleotide excision repair pathway
mmu03410
Base excision repair pathway
mmu03430
Mismatch repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8027
Processive synthesis on the C-strand of the telomere pathway
REACT_7961
Telomere C-strand (Lagging Strand) Synthesis pathway
REACT_1385
Processive synthesis on the lagging strand pathway
REACT_74
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_1998
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
REACT_977
Resolution of D-loop structures through Holliday junction intermediates pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_1874
Homologous Recombination Repair pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_899
S Phase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_2253
Global Genomic NER (GG-NER) pathway
REACT_7970
Telomere Maintenance pathway
REACT_2054
Double-Strand Break Repair pathway
REACT_115566
Cell Cycle pathway
REACT_228145
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) pathway
REACT_2229
Resolution of D-loop structures pathway
REACT_1104
Base Excision Repair pathway
REACT_1587
Homologous recombination repair of replication-independent double-strand breaks pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_932
DNA strand elongation pathway
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) pathway
REACT_228013
Mismatch Repair pathway
REACT_8030
Extension of Telomeres pathway
REACT_312
Lagging Strand Synthesis pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa03030
DNA replication pathway
hsa03420
Nucleotide excision repair pathway
hsa03430
Mismatch repair pathway
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3YUW4
UniProt Splice Variant
Entrez Gene 16881
UniGene
RefSeq NM_001083188 NM_001199310 NM_010715
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:101789
MGI Symbol Lig1
EMBL AC161792
GenPept
RNA Seq Atlas 16881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca