InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LIG1

Summary

InnateDB Gene

IDBG-640139.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIG1

Gene Name

DNA ligase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014595

Encoded Proteins

IDBP-692371

DNA ligase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105486:
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:55307590-55334837

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000031920

ENSBTAP00000031866

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding
GO:0016874	ligase activity

Biological Process

GO:0006260	DNA replication
GO:0006266	DNA ligation
GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0042542	response to hydrogen peroxide
GO:0051103	DNA ligation involved in DNA repair
GO:0071897	DNA biosynthetic process