Version 5.4
Homo sapiens Gene: CCNB2
Summary
InnateDB Gene IDBG-14456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNB2
Gene Name cyclin B2
Synonyms HsT17299
Species Homo sapiens
Ensembl Gene ENSG00000157456
Encoded Proteins
IDBP-14458
cyclin B2
IDBP-594150
cyclin B2
IDBP-812033
cyclin B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:59105078-59125045
Strand Forward strand
Band q22.2
Transcripts
ENST00000288207 ENSP00000288207
ENST00000561077
ENST00000559622 ENSP00000453685
ENST00000559301
ENST00000621385 ENSP00000480809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated
Total 33 [view]
Protein-Protein 31 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0007077 mitotic nuclear envelope disassembly
GO:0040007 growth
GO:0043029 T cell homeostasis
GO:0048538 thymus development
GO:0051301 cell division
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032218
View Gene Order
ENSBTAG00000005269
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_1846
G2/M DNA replication checkpoint pathway
REACT_1100
Golgi Cisternae Pericentriolar Stack Reorganization pathway
REACT_160122
Activation of NIMA Kinases NEK9, NEK6, NEK7 pathway
REACT_150260
Condensation of Prometaphase Chromosomes pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_2101
Cyclin B2 mediated events pathway
REACT_828
G2/M Checkpoints pathway
REACT_163931
Nuclear Pore Complex (NPC) Disassembly pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_2203
G2/M Transition pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
hsa04115
p53 signaling pathway pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004701
HUGO
OMIM
CCDS CCDS10170
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca