Version 5.4
Mus musculus Gene: Ssr1
Summary
InnateDB Gene IDBG-145489.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ssr1
Gene Name signal sequence receptor, alpha
Synonyms 2510001K09Rik; 6330400D04; AI159733; AI452176; SSR; TRAPA
Species Mus musculus
Ensembl Gene ENSMUSG00000021427
Encoded Proteins
IDBP-145493
signal sequence receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124783:
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. [provided by RefSeq, Jul 2008]
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:37971401-37994190
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000021864 ENSMUSP00000021864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124783
View Gene Order
ENSBTAG00000022731
Not yet available
Pathways
NETPATH
REACTOME
REACT_239697
Unfolded Protein Response (UPR) pathway
REACT_254308
Translation pathway
REACT_247926
Metabolism of proteins pathway
REACT_231085
IRE1alpha activates chaperones pathway
REACT_196445
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_233572
Gene Expression pathway
REACT_106572
XBP1(S) activates chaperone genes pathway
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_18273
XBP1(S) activates chaperone genes pathway
REACT_18368
IRE1alpha activates chaperones pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_71
Gene Expression pathway
REACT_221721
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_226022
Gene Expression pathway
REACT_209048
Translation pathway
REACT_218371
IRE1alpha activates chaperones pathway
REACT_213782
Metabolism of proteins pathway
REACT_211201
XBP1(S) activates chaperone genes pathway
REACT_226614
Unfolded Protein Response (UPR) pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q9CY50
TrEMBL
UniProt Splice Variant
Entrez Gene 107513
UniGene Mm.409778 Mm.426670 Mm.483350 Mm.490298
RefSeq NM_025965 XM_006516524
OMIM
CCDS CCDS26459
HPRD
IMGT
MGI ID MGI:105082
MGI Symbol Ssr1
EMBL AF326229 AF395811 AK010884 AK166235 AK167793 BC011255
GenPept AAH11255 AAK16151 AAK82421 BAB27245 BAE38650 BAE39823
RNA Seq Atlas 107513

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca