Version 5.4
Mus musculus Gene: Clcn2
Summary
InnateDB Gene IDBG-146154.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clcn2
Gene Name chloride channel 2
Synonyms AL118368; ClC-2; Clc2; nmf240
Species Mus musculus
Ensembl Gene ENSMUSG00000022843
Encoded Proteins
IDBP-146156
chloride channel 2
IDBP-401446
chloride channel 2
IDBP-537217
chloride channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114859:
This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:20702964-20717746
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000007207 ENSMUSP00000007207
ENSMUST00000120099 ENSMUSP00000112759
ENSMUST00000148131
ENSMUST00000153075
ENSMUST00000131522 ENSMUSP00000122921
ENSMUST00000144400
ENSMUST00000123417
ENSMUST00000131833
ENSMUST00000132512
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:0060041 retina development in camera-type eye
GO:0060689 cell differentiation involved in salivary gland development
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0034707 chloride channel complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114859
View Gene Order
ENSBTAG00000012284
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A9C437
UniProt Splice Variant
Entrez Gene 12724
UniGene Mm.177761
RefSeq NM_009900 XM_006521749
OMIM
CCDS CCDS28057
HPRD
IMGT
MGI ID MGI:105061
MGI Symbol Clcn2
EMBL AC087898 CT010490
GenPept
RNA Seq Atlas 12724

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca