InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BNIP2

Summary

InnateDB Gene

IDBG-14641.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BNIP2

Gene Name

BCL2/adenovirus E1B 19kDa interacting protein 2

Synonyms

BNIP-2; NIP2

Species

Homo sapiens

Ensembl Gene

ENSG00000140299

Encoded Proteins

IDBP-14643

BCL2/adenovirus E1B 19kDa interacting protein 2

IDBP-374131

BCL2/adenovirus E1B 19kDa interacting protein 2

IDBP-374135

BCL2/adenovirus E1B 19kDa interacting protein 2

IDBP-374138

BCL2/adenovirus E1B 19kDa interacting protein 2

IDBP-811913

BCL2/adenovirus E1B 19kDa interacting protein 2

IDBP-811921

BCL2/adenovirus E1B 19kDa interacting protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:59659146-59689534

Strand

Reverse strand

Band

q22.2

Transcripts

ENST00000267859	ENSP00000267859
ENST00000415213	ENSP00000412767
ENST00000439052	ENSP00000393644
ENST00000448414	ENSP00000398364
ENST00000417312
ENST00000478981
ENST00000464390
ENST00000477543
ENST00000560776
ENST00000560458
ENST00000557987
ENST00000607373	ENSP00000475320
ENST00000612191	ENSP00000479818

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001824	blastocyst development
GO:0006915	apoptotic process
GO:0042692	muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0043547	positive regulation of GTPase activity
GO:0045666	positive regulation of neuron differentiation
GO:0051057	positive regulation of small GTPase mediated signal transduction
GO:0051146	striated muscle cell differentiation
GO:0051149	positive regulation of muscle cell differentiation
GO:0051297	centrosome organization

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0005829	cytosol
GO:0031616	spindle pole centrosome
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000011958

View Gene Order

ENSBTAG00000013493

Not yet available

Pathways

NETPATH

REACTOME

REACT_21402

CDO in myogenesis pathway

REACT_111045

Developmental Biology pathway

REACT_21303

Myogenesis pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.592515 Hs.646490 Hs.702777 Hs.732824 Hs.741663

RefSeq

NM_004330

HUGO

OMIM

CCDS

CCDS10174

HPRD

04481

IMGT

EMBL

GenPept

RNA Seq Atlas