Version 5.4
Bos taurus Gene: PCSK4
Summary
InnateDB Gene IDBG-645644.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK4
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002305
Encoded Proteins
IDBP-698369
proprotein convertase subtilisin/kexin type 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115257:
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in reproduction and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein (proPACAP) and pro-insulin-like growth factor II. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:45508320-45513924
Strand Reverse strand
Band
Transcripts
ENSBTAT00000002975 ENSBTAP00000002975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0007339 binding of sperm to zona pellucida
GO:0007340 acrosome reaction
GO:0009566 fertilization
GO:0048240 sperm capacitation
Cellular Component
GO:0002080 acrosomal membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115257
View Gene Order
ENSMUSG00000020131
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_206713
NGF processing pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G5E527
UniProt Splice Variant
Entrez Gene
UniGene Bt.77029
RefSeq
HUGO HGNC:8746
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02020264 DAAA02020265
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca