Version 5.4
| Homo sapiens Gene: ZNF384 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-14787.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ZNF384 | ||||||||||||||||||
| Gene Name | zinc finger protein 384 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000126746 | ||||||||||||||||||
| Encoded Proteins |
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
zinc finger protein 384
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:6666477-6689572 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13.31 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Cross-References | |||||||||||||||||||
| SwissProt | Q8TF68 | ||||||||||||||||||
| TrEMBL | A9X424 A9X425 B4DQU6 D3DUR9 E9PHB3 F5GYZ1 F5H0D6 F5H105 F5H3Z9 F5H6N8 F5H8L7 F8W6Q3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 171017 | ||||||||||||||||||
| UniGene | Hs.103315 | ||||||||||||||||||
| RefSeq | NM_001039920 NM_001135734 NM_133476 XM_006718963 XM_006718964 XM_006718965 XM_006718966 | ||||||||||||||||||
| HUGO | HGNC:11955 | ||||||||||||||||||
| OMIM | 609951 | ||||||||||||||||||
| CCDS | CCDS31732 CCDS44817 CCDS8557 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB070238 AC125494 AK095734 AK298962 BC053361 CH471116 DQ323638 DQ323639 U80738 | ||||||||||||||||||
| GenPept | AAB91437 AAH53361 ABD27869 ABD27870 BAB85125 BAC04618 BAG61058 EAW88755 EAW88756 EAW88757 EAW88758 | ||||||||||||||||||
| RNA Seq Atlas | 171017 | ||||||||||||||||||