Version 5.4
Bos taurus Gene: TAX1BP1
Summary
InnateDB Gene IDBG-633540.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAX1BP1
Gene Name Tax1-binding protein 1 homolog
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019020
Encoded Proteins
IDBP-685259
Tax1-binding protein 1 homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 17283140
[Homo sapiens] TAX1BP1 is a nuclear receptor co-activator that forms a complex with the glucocorticoid receptor (NR3C1). TAX1BP1 can bind Tax, a human T-cell leukemia virus type 1 oncoprotein, directly and this induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the co-activator function of TAX1BP1.
PMID 20304918
[Homo sapiens] TAX1BP1 and TNFAIP3 (A20) inhibit antiviral signalling by targeting TBK1/IKKi kinases and disrupting the TRAF3-TBK1-IKKi signalling complex.
PMID 21765415
[Homo sapiens] TAX1BP1 phosphorylation by CHUK is pivotal for the proinflammatory cytokine-dependent assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation. (Demonstrated in mouse)
PMID 21765415
[Mus musculus] Tax1bp1 phosphorylation by Chuk is pivotal for the proinflammatory cytokine-dependent assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106052:
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:68775902-68859811
Strand Reverse strand
Band
Transcripts
ENSBTAT00000033663 ENSBTAP00000033573
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019900 kinase binding
Biological Process
GO:0006915 apoptotic process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000106052
View Gene Order
ENSMUSG00000004535
View Gene Order
Pathways
NETPATH
REACTOME
REACT_221101
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_213138
Immune System pathway
REACT_211149
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_216714
Innate Immune System pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_239142
Innate Immune System pathway
REACT_198532
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_230745
Immune System pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q2KJE0
TrEMBL
UniProt Splice Variant
Entrez Gene 535589
UniGene Bt.17392
RefSeq NM_001046409 XM_005205538 XM_005205539
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105389
GenPept AAI05390
RNA Seq Atlas 535589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca