InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ahsg

Summary

InnateDB Gene

IDBG-148706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ahsg

Gene Name

alpha-2-HS-glycoprotein

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022868

Encoded Proteins

IDBP-148708

alpha-2-HS-glycoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22842477

Ahsg is an endogenous ligand of Tlr4 that promotes inflammatory signalling leading to lipid-induced insulin resistance.

InnateDB Annotation from Orthologs

Summary

PMID 22842477

[Homo sapiens] AHSG is an endogenous ligand of TLR4 that promotes inflammatory signalling leading to lipid-induced insulin resistance. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145192:
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:22892042-22899438

Strand

Forward strand

Band

Transcripts

ENSMUST00000023583

ENSMUSP00000023583

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity

Biological Process

GO:0001503	ossification
GO:0006953	acute-phase response
GO:0010951	negative regulation of endopeptidase activity
GO:0030502	negative regulation of bone mineralization
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000145192

View Gene Order

ENSBTAG00000000522

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

P29699

TrEMBL

Q3UEK9

UniProt Splice Variant

Entrez Gene

11625

UniGene

RefSeq

NM_001276450 NM_013465

OMIM

CCDS

CCDS28071

HPRD

IMGT

MGI ID

MGI:107189

MGI Symbol

Ahsg

EMBL

AF007900 AJ002146 AK133523 AK149474 BC012678 BC019822 CH466521 S96534

GenPept

AAB22070 AAB81718 AAH12678 AAH19822 BAE21704 BAE28902 CAA05210 EDK97636

RNA Seq Atlas

11625