InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AHSG

Summary

InnateDB Gene

IDBG-634683.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHSG

Gene Name

Alpha-2-HS-glycoprotein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000522

Encoded Proteins

IDBP-686463

Alpha-2-HS-glycoprotein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22842477

[Homo sapiens] AHSG is an endogenous ligand of TLR4 that promotes inflammatory signalling leading to lipid-induced insulin resistance. (Demonstrated in mice)

PMID 22842477

[Mus musculus] Ahsg is an endogenous ligand of Tlr4 that promotes inflammatory signalling leading to lipid-induced insulin resistance.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145192:
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:81202132-81209114

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000673

ENSBTAP00000000673

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005515	protein binding

Biological Process

GO:0001503	ossification
GO:0006953	acute-phase response
GO:0010951	negative regulation of endopeptidase activity
GO:0030500	regulation of bone mineralization
GO:0030502	negative regulation of bone mineralization
GO:0050727	regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0031982	vesicle
GO:0065010	extracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000145192

View Gene Order

ENSMUSG00000022868

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

bmppathway

BMP receptor signaling

Cross-References

SwissProt

P12763

TrEMBL

B0JYN6 Q9TRP4

UniProt Splice Variant

Entrez Gene

280988

UniGene

Bt.23250

RefSeq

NM_173984

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC147948 BC151430 X16577

GenPept

AAI47949 AAI51431 CAA34596

RNA Seq Atlas

280988