Version 5.4
Bos taurus Gene: ALDH1A1
Summary
InnateDB Gene IDBG-632280.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH1A1
Gene Name Retinal dehydrogenase 1
Synonyms ALDH1
Species Bos taurus
Ensembl Gene ENSBTAG00000008103
Encoded Proteins
IDBP-683893
Retinal dehydrogenase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165092:
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:49354207-49408166
Strand Reverse strand
Band
Transcripts
ENSBTAT00000010661 ENSBTAP00000010661
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001758 retinal dehydrogenase activity
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0008152 metabolic process
GO:0008218 bioluminescence
GO:0042572 retinol metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165092
View Gene Order
ENSMUSG00000053279
View Gene Order
Pathways
NETPATH
REACTOME
REACT_226409
Phase 1 - Functionalization of compounds pathway
REACT_218176
Biological oxidations pathway
REACT_215931
Ethanol oxidation pathway
REACT_219139
Metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_34
Ethanol oxidation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
REACT_249802
Phase 1 - Functionalization of compounds pathway
REACT_260489
Ethanol oxidation pathway
REACT_188937
Metabolism pathway
REACT_232343
Biological oxidations pathway
KEGG
hsa00830
Retinol metabolism pathway
mmu00830
Retinol metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Propanoate metabolism pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Pyruvate metabolism pathway
INOH website
Valine Leucine Isoleucine degradation pathway
INOH website
Lysine degradation pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt P48644
TrEMBL
UniProt Splice Variant
Entrez Gene 281615
UniGene Bt.4732
RefSeq NM_174239
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105193 BT030667 L36128
GenPept AAA74234 AAI05194 ABS44983
RNA Seq Atlas 281615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca